Charles Ruthenberg, Executive Secretary of old CPA (1919–1920); Executive Secretary of WPA/W(C)P (May 1922–1927)
· Alfred Wagenknecht, Executive Secretary of CLP (1919–1920); of UCP (1920–1921)
· Charles Dirba, Executive Secretary of old CPA (1920–1921); of unified CPA (May 30, 1921–July 27, 1921)
· Louis Shapiro, Executive Secretary of old CPA (briefly, late 1920)
· L.E. Katterfeld, Executive Secretary of unified CPA (July 27, 1921–October 15, 1921)
· William Weinstone, Executive Secretary of unified CPA (October 15, 1921–February 22, 1922)
· Jay Lovestone Executive Secretary of unified CPA (February 22, 1922–August 22, 1922); of W(C)P/CPUSA (1927–1929)
· James P. Cannon, National Chairman of WPA (December 1921–1922)
· Caleb Harrison, Executive Secretary of WPA (December 1921–May 1922)
· Abram Jakira, Executive Secretary of unified CPA (August 22, 1922–dissolution of underground party in 1923)
· William Z. Foster, Party Chairman (1929–1934)
· Earl Browder, Party Chairman (1934–1945)
· Eugene Dennis, General Secretary (1945–1959) and
William Z. Foster, Party Chairman (1945–1957)
· Gus Hall, General Secretary (1959–2000)
· Sam Webb, Chairman (2000–present)